ПОКАЗАТЕЛИ КЛЕТОЧНОГО АУТОИММУНИТЕТА У ЖЕНЩИН РАЗЛИЧНЫХ ЭТНИЧЕСКИХ ГРУПП С УЧЕТОМ КЛИМАТОГЕОГРАФИЧЕСКИХ УСЛОВИЙ ПРОЖИВАНИЯ

amounts of ethanol solutions of 15.5 ml / kg and 40 ml / kg. When 
administered 15.5 ml / kg of 13% ethanol, significant stimulatory 
effect disappeared on day 2 and thereafter effect of ethanol was 
unstable. Repeated introduction of a large volume of ethanol 40 ml / kg 
(5%) showed increased locomotor activity within 7 days of observation.

It has been shown that in the first day of the experiment
the 

introduction of ethanol in a dose of 2 mg/kg caused significant 
analgesic effect when administered 15.5 ml / kg of 13% ethanol solution 
only. The next day all ethanol concentrations and volumes showed 
analgesic effect. The following repeated ethanol administrations led to 
the development of tolerance. The absence of significant effect of 
administration of 5 ml/ kg of 40% ethanol was observed on the third 
day. Tolerance to analgesic effect of administration of 15.5 ml / kg of 
13% ethanol solution occurred on day 5. Tolerance to the analgesic 
effect did not develop for 7 days of experiment when administered 40 ml 
/ kg of 5% ethanol solution.

Thus, as a result of our studies revealed that for the 

manifestation of the effect of ethanol and for development of tolerance 
to it the amount of ethanol-containing liquid in the stomach is 
important. At the same time, the more distended stomach and the lower 
the concentration of ethanol, the slower it develops tolerance to the 
stimulant and analgesic effect.

This work was supported by the Russian Foundation for Basic 

Research (grant № 15-04-01690).
REFERENCES

1.Sudakov S.K., Trigub M.M.  //Bull Exp Biol Med.
146. № 12. 604-607

(2008). 
2.Sudakov S.K., Trigub M.M., Bashkatova V.G. //Russian J. Addiction. № 
11. 38-42 (2009).
3.Sudakov S.K., Bashkatova V.G., Kolpakov A.A. et al., // Bull Exp Biol 
Med.
149. № 3. 244-246 (2010).  

4.Sudakov S.K., Bashkatova V.G. //Bull Exp Biol Med.
155. № 6. 664-666

(2013). 

5. Mitchell M.C. Jr., Teigen E.L., Ramchandani V.A. //Alcohol Clin. 

Exp. Res. 38 № 5. 1200-1204 (2014).
DOI:10.12737/12433

ПОКАЗАТЕЛИ КЛЕТОЧНОГО АУТОИММУНИТЕТА У ЖЕНЩИН РАЗЛИЧНЫХ 
ЭТНИЧЕСКИХ ГРУПП С УЧЕТОМ КЛИМАТОГЕОГРАФИЧЕСКИХ УСЛОВИЙ 

ПРОЖИВАНИЯ

Невзорова Е.В.**, Халимова Ф.Т.*,  Шукуров Ф.А.*

*Таджикский государственный медицинский университет им. Абуали ибни 

Сино, Таджикистан, **Липецкий государственный педагогический 

университет, РФ

farizakhalimova@gmail.com

Ключевые слова: клеточный аутоиммунитет, иммунограмма, антитела