ЭМОЦИОНАЛЬНО-МОТИВАЦИОННЫЕ РАССТРОЙСТВА У КРЫС, ПОДВЕРГНУТЫХ ВОЗДЕЙСТВИЮ ИНГИБИТОРОВ ДИПЕПТИДИЛПЕПТИДАЗЫ IV ДИПРОТИНА А И СИТАГЛИПТИНА В ПЕРВУЮ ПОСТНАТАЛЬНУЮ НЕДЕЛЮ

the cellular basis of arrhythmias during ischemia and reperfusion is a 
damage of the ionic membrane permeability, that caused by dysfunction 
of ion channels. Proteins HSP70, functioning as chaperone, inhibit 
dysfunction of membrane enzyme, as well as they limit the degradation 
of cardiomyocytes and thus they prevent the development of arrhythmias. 
Protective effects of HSP70 may be associated with antioxidant activity 
and with the ability to limit the accumulation of intracellular 
calcium. It is also possible that oligonucleotides, which is  included 
in this drug is able to induce other HSP with protective properties. 
There is reason to suppose that one of the mechanisms of derinat 
induced 
activation 
of 
HSP70 
synthesis 
is 
associated 
with 

immunomodulatory properties of this drug. It was shown that singlestranded DNA through TLR9-receptors may induce activation of NF-kB [3], 
which initiates the transcription of genes of proinflammatory cytokines 
and antimicrobial peptides in the nucleus. It is known that NF-kB 
triggers also transcription of many other genes, including  HSP70 [4]. 
It is likely that oligonucleotides contained in this drug  induce the 
HSP70 synthesis activation by the same mechanism. CONCLUSION:
These 

data support the fact that the activation of HSP70 synthesis, induced 
by derinat is one of the mechanisms that increase the resistance of the 
heart to the ischemic and reperfusion arrhythmias.
References

1. Kaplina E.N., Weinberg Yu.P. Derinat. Natural immunomodulators are 

for children and   adults. 2004. Moscow. 

2. Mestril R., Chi S.H., Sayen M.R. et al. 1994. V.93, №2. P.759-67.
3. Wagner H., Bauer S. //J Exp Med. 2006. Feb 20. V.203, №2. P.265
268. 

4. Wilhide M.E., Tranter M., Ren X. et al. //J Mol Cell Cardiol.

2011. V.51, №1. P.82-89. 

5. Yang L., Cai X., Liu J. et al. //PLoS One. 2013. Apr 30. V.8. 

№4:e62373. 
DOI:10.12737/12395

ЭМОЦИОНАЛЬНО-МОТИВАЦИОННЫЕ РАССТРОЙСТВА У КРЫС, ПОДВЕРГНУТЫХ 
ВОЗДЕЙСТВИЮ ИНГИБИТОРОВ ДИПЕПТИДИЛПЕПТИДАЗЫ IV ДИПРОТИНА А И 

СИТАГЛИПТИНА В ПЕРВУЮ ПОСТНАТАЛЬНУЮ НЕДЕЛЮ

Н.А.Крупина, Н.Н.Хлебникова, И.Н.Орлова

Лаборатория общей патологии нервной системы (зав. – член-корр. РАН 

В.К.Решетняк) ФГБНУ «Научно-исследовательский институт общей патологии 

и патофизиологии», Москва

krupina-na@yandex.ru Н.А.Крупина

Ингибиторы дипептидилпептидазы IV
дипротин А и ситаглиптин в 

условиях системного введения крысятам в первую неделю после рождения 
вызывают эмоционально-мотивационные нарушения в виде депрессивноподобного 
поведения, 
тревожности 
и 
скрытой 
агрессии 
у 
крыс 

подросткового возраста и взрослых животных.