ИССЛЕДОВАНИЕ МЕХАНИЗМОВ РАЗВИТИЯ АНЕМИИ ПРИ ВОЗДЕЙСТВИИ ПОЛИХЛОРИРОВАННЫХ БИФЕНИЛОВ

chemiluminescence (CL). The estimation of Н2О2induced luminol
dependent CL was carried out within 10 seconds on analyser AutoLuman 
Plus LB 953 of Berhold Technologies company (Germany). Statistical 
treatment was carried out via program Statistica 6.5.

Results

By comparison of free radical processes FRP with different levels 

of HbA1 it was stated that the content of EGH in plasma of patients in 
1st group was twice as high as in 2nd group. The lower factors of fast 
burst amplitude (H) by 27% (p<0,05) and an increase of light sum (Sm) 
by 38% (p<0,05) were revealed in blood of patients of 2nd
group as 

compared to patients with HbA1 at level 4,2-6,1. As for patients of 1st

group, after espousing to hypobaric oxygenation the decrease of EGH (by 
42%; p<0,05) and the increase of TPA (by 62%; p<0,05) could be seen in 
plasma. Within 3rd series of experiment the following changes in FRP 
were revealed. Introduction to cortexin forwarded the decrease of EGH 
for 82% (p<0,01) and 109% (p<0,01) of patients with HbA1 at levels 4,26,1 and 6,2-12,0 respectively. Introduction of pinealon forwarded EGH 
decrease only in 1st group (by 24%; p<0,05). Introduction to cortexin 
forwarded the decrease of TPA in blood plasma of patients in 1st group 
by 33% (p<0,05), and the increase  in 2nd group by 47% (p<0,05), as 
compared to control. Introduction to pinealon forwarded the increase of 
TPA in both groups (p<0,05). The CL factors, that is H and Sm, of 1st

group introduced to cortexin were much higher (p<0,05) than of cortexin 
2nd group, and especially than of pinealon 1st and 2nd groups. H and Sm 
factors in blood plasma, incubated with pinealon, didn’t differ within 
patients with different levels of HbA1; those
factors didn’t differ 

from control factors as well. 

The researches were held within scope of basic part of government 

business of Ministry of Education and Research № 1878 “The design of 
fundamental 
aspects 
of 
molecular 
diagnostics 
and 
mitochondrial 

pharmacology”. 

References
1.Skorik O.S., Ryabov M.P.. // Bulletin of BSU. – 2011. - № 12. –

P. 190-195.

2.Giacco F.,. // Circulation Research. – 2010. – V. 107. - № 9. –

Р. 1058-1070.

3.Youn J.-Y., Siu K.L., Lob H.E. et al.. // Diabetes. – 2014. – V. 

63. - № 7. – Р. 2344-2355.

DOI:10.12737/12365

ИССЛЕДОВАНИЕ МЕХАНИЗМОВ РАЗВИТИЯ АНЕМИИ ПРИ ВОЗДЕЙСТВИИ 

ПОЛИХЛОРИРОВАННЫХ БИФЕНИЛОВ

Р.Р.Каримов, И.Р.Габдулхакова, А.Р.Шамратова, М.Я.Фазлыахметова, 

К.Р.Зиякаева, О.В.Самоходова, А.Ф.Каюмова

Кафедра нормальной физиологии Башкирского государственного медицинского 

университета, Уфа
annikachka@live.ru