ЦЕНТРАЛЬНЫЕ ЭФФЕКТЫ АНГИОТЕНЗИНА II ПРИ ДВУХ МОДЕЛЯХ ФОРМИРОВАНИЯ ИСКУССТВЕННОЙ АЛКОГОЛЬНОЙ ЗАВИСИМОСТИ У КРЫС

LEO 1450 VP scanning electron microscope (100-500, 2000-5000; Carl 
Zeiss, Германия). The results were subjected to analytical processing.

Studying with a binocular magnifier showed that irrigation of the 

minipig tongue with gastric juice is accompanied by a change in color 
of the mucous membrane. A pale-rose color was transformed into an ashypearl color. Light opalescence was typical of the back of the tongue. 
The degree of opalescence was shown to decrease in the root of the 
tongue. These features were observed in the frontal, middle, and distal 
zones of the tongue. Macroscopic
changes were reflected in a fine 

(microscopic) structure of the tongue. The tongue relief tended to be 
smoothened on a gastric juice-treated surface. Aiguilles of the 
circumvallate papillae (receptors for bitter tastes) were revealed 
under normal conditions, but disappeared in the zone of keratinization. 
It was probably related to desquamation of these structures. Then we 
evaluated the action of an aggressive agent (gastric juice) on 
fungiform papillae of the tongue, which serve as receptors for sweet 
and salt tastes. The vallecula around these papillae had a great number 
of folds. The prominence of the “fungus” was smoothened. In some 
regions, folate papillae of the tongue (receptors for acid tastes) 
appeared as cone-shaped outgrowths and lost an elongated
shape. 

Sometimes these structures were broken out, which resulted in the 
formation of traces of formerly existing papillae. It should be 
emphasized that the relief of the tongue mucous membrane was also 
smoothened, which resulted from alteration with the acid content.

Hence, experimental modeling of GERD in minipigs is followed by 

the appearance of macroscopic and morphological signs that illustrate 
an aggressive effect of gastric juice on the tongue mucous membrane. 
Our results and published data indicate that these changes contribute 
to stomatological manifestations of GERD in patients.
REFERENCES
1.
E. A. Bazikyan, I. V. Maev, and G. I. Lukina, Rossiiskaya 

Stomatologiya, No. 2, 3-5 (2013).
2.
S. M. Budylina and V. M. Smirnov, Manual to the Practicum in 

Normal Physiology [in Russian], Moscow (2005), 245-246.
3.
V. T. Ivashkin and A. S. Trukhmanov, Rossiiskii Zhurnal 

Gastroenterologii, Gepatologii, Koloproktologii, No. 2, 13-19 (2010).
4.
I. V. Maev, D. N. Andreev, and D. T. Dicheva, Gastroenterologiya, 

No. 8, 30-34 (2013).
5.
E. V. Pustovoit and E. N. Polikanova, Rossiiskaya Stomatologiya, 

No. 3, 12-15 (2009).
DOI:10.12737/12390

ЦЕНТРАЛЬНЫЕ ЭФФЕКТЫ АНГИОТЕНЗИНА II ПРИ ДВУХ МОДЕЛЯХ 

ФОРМИРОВАНИЯ ИСКУССТВЕННОЙ АЛКОГОЛЬНОЙ ЗАВИСИМОСТИ У КРЫС

А.В. Котов

ФГБНУ НИИ нормальной физиологии имени П.К.Анохина», Москва, РФ

lab_motiv@mail.ru , Котов А.В.