РАСПРЕДЕЛЕНИЕ РИТМОВ ЭЭГ ПРИ ФИЗИЧЕСКИХ НАГРУЗКАХ ЦИКЛИЧЕСКОЙ И СИЛОВОЙ НАПРАВЛЕННОСТИ

human duodenal mucosa biopsies [1], we have shown for the first time 
that cathepsin G is synthesized not only by the innate immune cells 
(neutrophils, mast cells, monocytes), but also by epithelial cells 
located in the bottom of intestinal crypts Paneth cells (PC). 

Cathepsin G-specific immunofluorescence was detected in the PC zone of 
rough endoplasmic reticulum, in the area of secretory granules and in 
the lumen of the intestinal crypt [1]. PC secretes into the lumen of 
the intestinal crypt the antimicrobial factors which protect stem cells 
of 
the 
intestinal 
epithelium 
against 
damage 
by 
pathogenic 

microorganisms. Our results about the immunolocalization of cathepsin G 
indicate constant presence of this protease in intestinal epithelium 
area, which can make significant adjustments in understanding of 
cathepsin G role in the intestinal mucosa physiology. It was 
established that goblet cells are the source of renin biosynthesis in 
rat intestinal epithelium [4]. It is known that renin, located on top 
of the RAS activation cascade, is synthesized as an inactive precursor 
- prorenin, activation of which may occur by proteolytic processing of 
cathepsin G [3].

Data presented in this paper about cathepsin G localization 

together with above mentioned published data give reason to assume the 
existence of cathepsin G-dependent pathway of local RAS activation in 
small intestine, where cathepsin G plays a key role in initiating the 
emergence of active AT-II in the intestinal epithelium.

REFERENCES
1. Zamolodchikova T.S., Scherbakov I.T., Khrennikov B.N., 

Svirshchevskaya E.V. // Biochemistry (Mosc). 2013. V. 78. N. 8. P. 954957.

2. Garg M., Angus P. W., Burrell L. M., Herath C. P., Gibson R.,  

Lubel J. S. // Aliment. Pharmacol. Ther. 2012. V. 35. N 4. P. 414–428.

3. Dzau V.J., Gonzalez D., Kaempfer C., Dubin D., Wintroub B.U. // 

Circ. Res. 1987. V. 60. N 4. P. 595-601.

4. Shorning B.Y., Jardé T., McCarthy A., Ashworth A., de Leng 

W.W., Offerhaus G.J., Resta N., Dale T. , Clarke A.R. // Gut 2012. V. 
61. N 2. P. 202-213.

5. Pham C.T. // Nat. Rev. Immunol. 2006. V. 6. N. 7, P. 541-550.

DOI:10.12737/12351

РАСПРЕДЕЛЕНИЕ РИТМОВ ЭЭГ ПРИ ФИЗИЧЕСКИХ НАГРУЗКАХ ЦИКЛИЧЕСКОЙ

И СИЛОВОЙ НАПРАВЛЕННОСТИ

А.Н. Захарова, А.В. Кабачкова, Г.С. Лалаева, Л.В. Капилевич

Национальный исследовательский Томский государственный университет, 

Томск, Россия

azakharova91@gmail.com

В исследовании представлены данные об особенностях распределения и 

доминирования основных ритмов ЭЭГ (альфа-, бета-, тета- и дельта-ритмы) 
у 
обследуемых 
при 
предъявлении
циклических 
(бег) 
и 
силовых 

(пауэрлифтинг) нагрузок. Следует отметить высокий индекс дельта-ритма в