ГЕМОДИНАМИКА И ВАРИАБЕЛЬНОСТЬ СЕРДЕЧНОГО РИТМА ПРИ НАПРЯЖЕННОЙ ИНТЕЛЛЕКТУАЛЬНОЙ ДЕЯТЕЛЬСТИ СТУДЕНТОВ ПРИ РЕШЕНИИ КОМПЬЮТЕРНЫХ УЧЕБНЫХ ТЕСТОВ

immunosuppression in tissues of studied brain structures in comparison 
with the control group №1 decreased: activity of the GAD in tissue of 
the cerebellum is 20,15 ± 1,05, visual cortex - 16,25 ± 1,25, the motor 
cortex - 14,52 ± 1,38, hypothalamus - 17,46 ± 1,18 mkmol GABA/h per 1 g 
of tissue. The activity of the enzyme GABA-T in the tissues of the 
cerebellum 68,64 ± 2,52, the visual cortex 58,32 ± 2,18, motor 

cortex - 57,85 ± 1,75, the hypothalamus - 88,28 ± 2,84 mkmol Glu/h per 
1 g of tissue. It was found that of 10-day-old rats after effect 
thymalinum in CPA immunosuppression the activity of the GAD increases: 
in the cerebellum - 23%, the hypothalamus - 56%, the visual cortex 36% of the motor cortex 49% relative to a control number 2. The 

activity of GABA-T in the tissues of studied brain structures 7-13% 
decreases compared with the control group №2.

Thus, after the action thymalinum in CPA immunosuppression in 

tissues of studied brain structures of 10-day old rats increased GABA 
content, on the one side, by enhancing its synthesis from Glu increased 
activity resulting from the GAD, on the other side, due to its use of 
small (GABA shunt), which is caused by inhibition of GABA-T activity. 
Experiments on the corrective properties thymalinum formed under immune 
deficiency showed that after immunosuppression administration of the 
drug promotes recovery of activity of the GAD and GABA-T. It is found 
that act through immunomodulatory cytokine cascades. Thymus peptides 
activated T cellular
immunity and increased production of various 

cytokines: IL-1, IL-2, IL-6, IL-8, FNOα, IFγ. IL-1 is considered to be 
binding mediator between the immune and neuroendocrine systems. IL-1 
increases 
the 
levels 
of 
serotonin 
in 
the 
hypothalamus 
and 

noradrenaline. Due to the fact that the effect of thymic peptides on 
GABAergic system implemented in interaction with the serotonergic and 
dopaminergic systems. On the basis of the obtained results and 
literature data it is possible to make the conclusion that thymalinum 
regulates the exchange of GABA in the CNS in CPA immunosuppression.

REFERENCES
1.
Novoseletskaya A.N., Kiseleva N.M., Inozemtsev A.N. et al. 

//J. Russ. Immunol. 2012. Vol. 6(15), №4. P.395-398

2.
Tyurenkov I.N., Samatrueva M.A., Serezhnikova T.K. //Exp. 

and Сlin. Pharmacol. 2011. Vol.74, №11. P.36-42

3.Fleshner M., Laudenslager M.L. // Behav. Cogn. Neurosci. Re
DOI:10.12737/12289

ГЕМОДИНАМИКА И ВАРИАБЕЛЬНОСТЬ СЕРДЕЧНОГО РИТМА ПРИ 

НАПРЯЖЕННОЙ ИНТЕЛЛЕКТУАЛЬНОЙ ДЕЯТЕЛЬСТИ

СТУДЕНТОВ ПРИ РЕШЕНИИ КОМПЬЮТЕРНЫХ УЧЕБНЫХ ТЕСТОВ

В.В Андрианов, Н.А.Василюк*, Е. В Бирюкова

Кафедра нормальной физиологии, ГБОУ ВПО Первый Московский 

государственный медицинский университет имени И.М.Сеченова Минздрава 

России, 

*ФГБНУ «Научно-исследовательский институт нормальной физиологии имени 

П.К.Анохина», Москва, Россия.

avvn2010@mail.ru