СОДЕРЖАНИЕ МИНОРНЫХ СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ В ПЕРИФЕРИЧЕСКОЙ КРОВИ ДЕТЕЙ С БРОНХОЛЕГОЧНОЙ ПАТОЛОГИЕЙ

multiple regression and correlation analysis results [1] we analyzed 
the association between the functional state of various systems and the 
endogenous concentration of chemical elements and major environmental 
pollutants, the relation between them and the type of adaptive response  
to the current environmental conditions.

Results suggest that even relatively low concentrations of toxic 

elements (lead, mercury, cadmium, arsenic, etc) at background exposure 
in the urban and industrial polluted environment of the Crimean 
peninsula show some significant effects on the functional state of the 
examined systems. And organism’s adaptation to the environment 
increases in case of highly modified environment, especially if a 
complex action of factors is considered, for example, analyzing not the 
impact of the single element, but the effects of the elements’ 
imbalance altogether. Such xenobiotics as persistent organic compounds 
(pesticides) produce stronger effects on functions of the organism. 
Each of the examined systems can be considered as the potential target 
for the pollutants, but their sensitivity significantly varies. Effects 
of heavy metals on the CVS functional state are hidden and could be 
revealed only during functional tests indicating partial or compensated 
adaptation. While electrophysiological characteristics appeared to be 
the most sensitive to changes in the internal content of pollutants, 
suggesting 
that 
the 
evaluation 
of 
early 
adverse 
effects 
of 

anthropogenic influence should be assessed first based on functional 
state of the CNS due to its importance in the adaptation of the 
organism in a relatively rapid anthropogenic modification of the 
environment.

References.
1. Evstafyeva E.V. Environmental  Risk Assessment for Health in 

the Republic of Crimea // Issues of Risk Analysis. 2014, V.11, 
№ 5. P. 30-38.

DOI:10.12737/12344

СОДЕРЖАНИЕ МИНОРНЫХ СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ 

В ПЕРИФЕРИЧЕСКОЙ КРОВИ ДЕТЕЙ С БРОНХОЛЕГОЧНОЙ ПАТОЛОГИЕЙ

М.В. Ефименко, Г.П. Евсеева, Л.А. Ли, Е.Н. Супрун

Хабаровский филиал Дальневосточного научного центра физиологии и 

патологии дыхания – НИИ охраны материнства и детства (директор – д.м.н. 

О.А. Лебедько)
m.efimencko@yandex.ru

Ключевые слова: минорные субпопуляции, бронхолегочная патология, 

дети

В настоящее время определение субпопуляционного состава и фенотипа 

лимфоцитов является важным диагностическим признаком для выяснения 
нарушений, связанных с функционированием иммунной системы. В процессе 
исследований значительно расширились представления о функционировании 
системы иммунитета и появились сообщения, что, в периферической крови и 
органах иммунной системы выявляется популяция дубль-позитивных (D