Фармакотерапия неотложных состояний

CRITICAL CARE 
PHARMACOTHERAPY 

Editor 
Bart Chernow, M.D., F.A.C.P. 

Professor of Medicine 
Anesthesia and Critical Care 
The Johns Hopkins University 
School of Medicine 

Physician-in-Chief 
Sinai Hospital of Baltimore 
Baltimore, Maryland 

Editorial Associate 
Lisa Daniel Sparks 

Material adapted from «The Pharmacologic Approach to the 
Critically Ill Patient», Third Edition 

Williams & Wilkins 

BALTIMORE • PHILADELPHIA •HONG KONG 
LONDON •MUNICH •SYDNEY •TOKYO 

A WAVERLY COMPANY 

POCKET BOOK OF

ФАРМАКОТЕРАПИЯ 
НЕОТЛОЖНЫХ 
СОСТОЯНИЙ 

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for Знаниум

POCKET BOOK OF
СПРАВОЧНИК 

УДК 616-083.98:615.03 
ББК 53.52 
       Ч49 

Чернов Б. 
Фармакотерапия неотложных состояний: Справочник / Пер. с 
англ. под ред. д.м.н., проф. М. К. Кевры, к.м.н., доц. Ю. В. 
Алексеенко. — М.: Медицинская литература, 2021.— 363 с.: ил. 

ISBN 978-5-89677-001-5 

В популярном американском справочнике изложены основные понятия 

фармакокинетики, приведены наиболее значимые лекарственные взаимодействия, освещены некоторые разделы клинической фармакологии широко применяемых групп препаратов, даны рекомендации по фармакотерапии распространенных патологических состояний. Особую ценность и интерес представляют 
главы, посвященные особенностям фармакотерапии в условиях нарушения 
функций печени и почек. 
Для терапевтов, реаниматологов, неврологов, педиатров и врачей других 
специальностей. 

Ч49 

УДК 616-083.98:615.03 

ББК 53.52

ISBN 978-5-89677-001-5 
ISBN 0-683-01535-4 (англ.)

 Изд. Чернин Б.И., изд. Плешков Ф.И., 
перевод на русский язык, оформление, 2021 
 Williams & Wilkins 

Translated and published by Agreement with the Original Publisher, Williams & Wilkins, 
USA. 
Подготовлено к печати по договору с издательством Williams & Wilkins, США. 

Все права защищены. Никакая часть данной книги не может быть воспроизведена в 
любой форме и любыми средствами без письменного разрешения владельцев авторских прав. 

Авторы, редакторы и издатели приложили все усилия, чтобы обеспечить точность 
приведенных в данной книге показаний, побочных реакций и рекомендуемых доз 
лекарств. Однако эти сведения могут изменяться. Внимательно изучайте сопроводительные инструкции изготовителя по применению лекарственных и технических средств.  

СОДЕРЖАНИЕ 

Àâòîðû 
VI

Ïðåäèñëîâèå 
X 

Ñïèñîê ñîêðàùåíèé 
XII

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1

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11

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37

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73

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113

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147

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м,%!ел=*“=…2%" 
163

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175

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!=““2!%L“2" 
197

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11 o!еC=!=2/ дл  лече…,  ,…-е*ц,%……/. ƒ=K%ле"=…,L 
267

12 t=!м=*%2е!=C,  .…д%*!,……/. , ме2=K%л,че“*,. 
!=““2!%L“2" 
301

Ïðåäìåòíûé óêàçàòåëü 
313

Фармакотерапия неотложных состояний 
VI

АВТОРЫ 

David M. Angaran, M.S., F.C.C.P., F.A.S.H.P. 
Professor of Pharmacy 
Co-Director, Dubow Family Center for 
Research in Pharmaceutical Care 
University of Florida College of Pharmacy 
Gainesville, Florida 

Patricia A. Arns, M.D. 
Staff Physician in Intemal Medicine 
Baptist Hospital 
Nashville, Tennessee 

Frank J. Balestrieri, D.D.S., M.D., F.C.C.P. 
Medical Director, Woodburn Surgery Center 
Fairfax Hospital 
Falls Church, Virginia 
Assistant Clinical Professor 
Department of Anesthesiology George 
Washington University School of Medicine 
Washington, DC 
Assistant Clinical Professor 
Department of Anesthesiology Bowman Gray 
School of Medicine 
Winston-Salem, North Carolina 

Luca M. Bigatello, M.D. 
Instructor in Anesthesia 
Harvard Medical School 
Department of Anesthesia 
Massachusetts General Hospital 
Boston, Massachusetts 

William P. Boyer, M.D. 
Assistant Professor 
Department of Psychiatry 
Emory University Atlanta, Georgia 

Robert A. Branch, M.D. 
Professor of Medicine, Pharmacy, Pharmacology 
and Therapeutics 
Director, Center for Clinical Pharmacology 
University of Pittsburgh Medical Center 
Pittsburgh, Pennsylvania 

D. Craig Brater, M.D.
John B. Hickam Professor of Medicine
Chairman, Department of Medicine
Professor of Pharmacology and Toxicology
Chief, Division of Clinical Pharmacology
Indiana University Medical Center
Indianapolis, Indiana

Kenneth D. Burman, M.D., Col., M.C. 
Professor of Medicine 
Department of Medicine 
The Uniformed Services University of the 
Health Sciences School of Medicine 
Director, Section of Endocrinology 
Washington Hospital 
Washington, DC 

Edwin H. Cassem, M.D. 
Associate Professor of Psychiatry 
Harvard University School of Medicine 
Chief, Department of Psychiatry 

Massachusetts General Hospital 
Boston, Massachusetts 

Robert Chasse, M.D. 
Clinical Instructor 
Section of Pulmonary/Critical Care Medicine 
Department of Internal Medicine 
Bowman Gray School of Medicine 
Wake Forest University 
Winston-Salem, North Carolina 

Bart Chernow, M.D., F.A.C.P. 
Professor of Medicine, Anesthesia, and Critical 
Care 
The Johns Hopkins University School of 
Medicine 
Physician-in-Chief 
Sinai Hospital of Baltimore 
Baltimore, Maryland 
Editor-in-Chief 
Critical Care Medicine 

Robert Chin, Jr., M.D., F.C.C.P. 
Assistant Professor of Medicine 
Section of Pulmonary and Critical Care 
Medicine 
Department of Medicine 
Bowman Gray School of Medicine 
Wake Forest University 
Winston-Salem, North Carolina 

Robert D. Colucci, Pharm.D., F.C.P., F.C.C.M. 
Assistant Director 
Clinical Pharmacology, Clinical Research 
Schering Plough Research Institute 
Kenilworth, New Jersey 

David J. Cullen, M.D., M.S. 
Professor of Anesthesia 
Harvard Medical School 
Anesthetist, Department of Anesthesia 
Massachusetts General Hospital 
Boston, Massachusetts 

Harold J. DeMonaco, M.S. 
Assistant Professor 
MGH Institute of Health Professions 
Director, Pharmacy Department 
Massachusetts General Hospital 
Boston, Massachusetts 

Douglas S. DeWitt, Ph.D. Associate Professor 
Department of Anesthesiology 
Director, Charles R. Allen Research Laboratories 
University of Texas Medical Branch 
Galveston, Texas 

Michael N. Diringer, M.D. 
Assistant Professor of Neurology, Neurosurgery, 
and Anesthesiology 
Director, Neurology/Neurosurgery Intensive 
Care Unit 
Washington University School of Medicine 
St. Louis, Missouri 

Авторы 
VII

Sudhir K. Dutta, M.D., F.A.C.P. 
Professor of Medicine 
University of Maryland School of Medicine 
Director, Division of Gastroenterology 
Sinai Hospital of Baltimore 
Baltimore, Maryland 

Donald Charles Eagerton, M.D. 
Clinical Instructor of Medicine 
Division of Endocrinology 
Medical University of South Carolina 
Charleston, South Carolina 

Sherry Fisher, R.N. 
Pain Management Coordinator 
Department of Anesthesiology 
Fairfax Hospital 
Falls Church, Virginia 

Robert M. Forstot, M.D. 
Instructor of Anesthesiology 
Division of Cardiothoracic Anesthesia 
Department of Anesthesiology 
Washington University School of Medicine 
St. Louis, Missouri 

David W. Fuhs, Pharm.D., M.S. 
Assistant Director of Pharmacy 
United and Children's Hospitals 
St. Paul, Minnesota 
Clinical Assistant Professor 
Department of Pharmacy Practice 
University of Minnesota College of Pharmacy 
Minneapolis, Minnesota 

Marye H. Godinez, M.D. 
Research Associate 
The Joseph Stokes Jr. Research Institute 
The Children's Hospital of Philadelphia 
Philadelphia, Pennsylvania 

Rodolfo L Godinez, M.D., Ph.D. 
Associate Professor of Anesthesiology and 
Pediatrics 
University of Pennsylvania School of Medicine 
Associate Medical Director, Pediatric Intensive 
Care Unit 
Medical Director, Respiratory Care Services 
The Children's Hospital of Philadelphia 
Philadelphia, Pennsylvania 

John P. Grant, M.D. 
Associate Professor of Surgery 
Duke University Medical Center 
Durham, North Carolina 

David J. Greenblatt, M.D. 
Professor 
Department of Pharmacology and Experimental 
Therapeutics 
Tufts University School of Medicine 
Division of Clinical Pharmacology 
New England Medical Center Hospital 
Boston, Massachusetts 

Ake N. A. Grenvik, M.D., Ph.D., F.C.C.M. 
Professor of Anesthesiology, Medicine, and 
Surgery 
Director, Multidisciplinary Critical Care 
Training Program 
University of Pittsburgh School of Medicine 

Pittsburgh, Pennsylvania 

Charles E. Halstenson, Pharm.D., F.C.C.P. 
Professor of Pharmacy 
University of Minnesota College of Pharmacy 
Co-Director, The Drug Evaluation Unit 
Minneapolis Medical Research Foundation at 
Hennepin County Medical Center 
Minneapolis, Minnesota 

Paul M. Heerdt, M.D., Ph.D. 
Associate Professor 
Department of Anesthesiology 
Assistant Professor 
Department of Pharmacology 
Cornell University Medical College 
Assistant Member 
Department of Anesthesiology and Critical Care 
Medicine 
Memorial Sloan-Kettering Cancer Center 
New York, New York 

Allan S. Jaffe, M.D. 
Professor of Medicine 
Cardiovascular Division 
Washington University School of Medicine 
St. Louis, Missouri 

Jeffrey S. Kelly, M.D. 
Assistant Professor of Anesthesia/ 
Critical Care 
Bowman Gray School of Medicine 
Department of Anesthesia 
Wake Forest University 
Winston-Salem, North Carolina 

David J. Kramer, M.D. 
Assistant Professor of Anesthesiology/ 
Critical Care Medicine 
University of Pittsburgh School of Medicine 
Co-Director, Liver Transplant ICU Services 
University of Pittsburgh Medical Center 
Pittsburgh, Pennsylvania 

Gregory L. Krauss, M.D. 
Assistant Professor 
Department of Neurology 
The Johns Hopkins University School of 
Medicine 
Baltimore, Maryland 

Cheryl A. Kubisty, M.D. 
Providence Everett Primary Care 
Everett, Washington 

C. Raymond Lake, M.D., Ph.D. 
Professor and Chairperson 
Department of Psychiatry and Behavioral 
Sciences 
University of Kansas School of Medicine 
Kansas City, Kansas 

Daniel J. Lebovitz, M.D. 
Assistant Professor of Pediatrics 
Department of Pediatric Critical Care Medicine 
Children's Hospital of Oklahoma 
Oklahoma City, Oklahoma 

Brian Litt, M.D. 
Assistant Professor 
Departments of Neurology and Medicine 

Фармакотерапия неотложных состояний 
VIII

The Johns Hopkins University School of 
Medicine 
Director of Neurophysiology 
Division of Neurology 
Department of Medicine 
Sinai Hospital of Baltimore 
Baltimore, Maryland 

Drew A. MacGregor, M.D. 
Assistant Professor of Anesthesia (Critical Care) 
and Medicine (Pulmonary/Critical Care) 
Department of Anesthesia 
Bowman Gray School of Medicine 
Wake Forest University 
Winston-Salem, North Carolina 

J. A. Jeevendra Martyn, M.D., F.F.A.R.C.S. 
Professor of Anesthesiology 
Harvard  Medical School 
Director, Clinical Pharmacology 
Massachusetts General Hospital 
Associate Director of Anesthesia 
Shriners Burn Institute 
Boston, Massachusetts 

Henry Masur, M.D. 
Chief, Critical Care Medicine 
Clinical Center, National Institutes of Health 
Bethesda, Maryland 
Professor of Clinical Medicine 
George Washington University Medical Center 
Washington, DC 

Daniel A. Notterman, M.D., F.A.A.P., F.C.C.M 
Associate Professor of Pediatrics, Clinical 
Pharmacology, and Pediatrics in Surgery 
Director, Division of Pediatric Critical Care 
Medicine 
The New York Hospital-Cornell Medical Center 
New York, New York 
Research Scientist 
Department of Molecular Biology 
Princeton University 
Princeton, New Jersey 

Joseph E. Parrillo, M.D. 
James B. Herrick Professor of Medicine 
Chief, Sections of Cardiology and Critical Care 
Medicine 
Medical Director, Rush Heart Institute 
Rush-Presbyterian-St. Luke's Medical Center 
Chicago, Illinois 

Donald S. Prough, M.D. 
Professor and Chairman 
Department of Anesthesiology 
University of Texas Medical Branch 
Galveston, Texas 

Russell C. Raphaely, M.D. 
Professor of Anesthesia and Pediatrics 
University of Pennsylvania School of Medicine 
Director of Critical Care Medicine 
Department of Anesthesiology/Critical Care 
Medicine 
The Children's Hospital of Philadelphia 
Philadelphia, Pennsylvania 

Michael D. Reed, Pharm.D., F.C.C.P, F.C.P. 
Associate Professor 

Department of Pediatrics 
Case Westem Reserve University School 
of Medicine 
Division of Pediatric Pharmacology and Critical 
Care 
Rainbow Babies and Children's Hospital 
Cleveland, Ohio 

Alan J. Rosenbloom, M.D. 
Assistant Professor of Anesthesiology/Critical 
Care Medicine 
Division of Critical Care Medicine, Department 
of Anesthesiology 
University of Pittsburgh School of Medicine 
Pittsburgh, Pennsylvania 

Laurence H. Ross, M.D. 
Baltimore, Maryland 

Anita C. Rudy, Ph.D. 
Lecturer 
Department of Medicine 
Indiana University Medical Center 
Indianapolis, Indiana 

Pablo F. Ruiz-Ramon, M.D. 
Co-Director, Northern California Renal 
Transplant Program 
Department of Medicine 
Santa Rosa Memorial Hospital 
Clinical Instructor, Community Hospital 
Residency Program 
Santa Rosa, California 

Michael Salem, M.D. 
Assistant Professor of Surgery and Anesthesia 
Director, Surgical Critical Care and Surgical 
Research 
George Washington University Medical Center 
Washington, DC 

Joseph M. Scavone, M.S., Pharm.D. 
Professor and Division Head 
Division of Clinical and Administrative 
Pharmacy 
College of Pharmacy 
University of Iowa 
Iowa City, Iowa 

Marissa Seligman, Pharm.D. 
Vice President, Academic and Scientific Affairs 
SCP Communications, Inc. 
New York, New York 

Henry J. Silverman, M.D. 
Associate Professor of Medicine 
Director, Medical Intensive Care Unit 
Pulmonary and Critical Care Medicine Division 
University of Maryland School of Medicine 
Baltimore, Maryland 

John C. Somberg, M.D., F.C.P. 
Professor of Medicine and Pharmacology 
Chief, Division of Clinical Pharmacology and 
Cardiology 
The Chicago Medical School 
North Chicago, Illinois 

Rajat Sood, M.D. 
Fellow in Gastroenterology 
Department of Medicine 

Авторы 
IX

Henry Ford Hospital 
Detroit, Michigan 

Wendy L. St. Feter, Pharm.D. 
Assistant Professor of Pharmacy 
University of Minneapolis College of Pharmacy 
Clinical Scientist 
The Drug Evaluation Unit 
Hennepin County Medical Center 
Minneapolis, Minnesota 
Keith L. Stein, M.D. 
Chief, Critical Care 
Department of Anesthesiology/Critical Care 
Medicine 
Mayo Clinic, Jacksonville 
Jacksonville, Florida 

Barney J. Stern, M.D. 
Professor of Neurology 
Department of Neurology 
Emory University 
Atlanta, Georgia 

Neelakantan Sunder, M.B.B.S. 
Assistant Professor of Anesthesia 
Harvard Medical School 
Associate Anesthetist, Massachusetts 
General Hospital 
Boston, Massachusetts 

Bertil K. J. Wagner, Pharm.D. 
Assistant Professor 
Department of Pharmacy Practice 
Rutgers-The State University of New Jersey 
College of Pharmacy 
Adjunct Assistant Professor 
Department of Surgery and Anesthesia 
UMDNJ # Robert Wood Johnson Medical 
School 

Piscataway, New Jersey 

Peter J. Wedlund, Ph.D. 
Associate Professor of Pharmacology 
University of Kentucky College of Pharmacy 
Lexington, Kentucky 

Howard D. Weiss, M.D. 
Assistant Professor of Neurology 
The Johns Hopkins University School of 
Medicine 
Division of Neurology 
Sinai Hospital of Baltimore 
Baltimore, Maryland 

Gary P. Zaloga, M.D., F.A.C.P. 
Professor of Medicine and Anesthesia/Critical 
Care Medicine 
Head, Section on Critical Care 
Department of Anesthesia 
Bowman Gray School of Medicine 
Wake Forest University 
Winston-Salem, North Carolina 

Arno L. Zaritsky, M.D. 
Associate Professor of Pediatrics 
Eastern Virginia Medical School 
Co-Director, Pediatric ICU 
Children's Hospital of The King's Daughters 
Norfolk, Virginia 

Michael G. Ziegler, M.D. 
Professor of Medicine 
Director, Hypertension Services 
Program Director, Clinical Research Center 
University of California, San Diego Medical 
Center 
San Diego, California

 

ПРЕДИСЛОВИЕ АВТОРА 
К РУССКОМУ ИЗДАНИЮ 
 
 
 
 
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Pharmacologic Approach to the Critically Ill Patient». 
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Bart Chernow, MD, FACP 
Professor of Medicine 
The Johns Hopkins University School of Medicine 
Program Director, 
Johns Hopkins University/Sinai Hospital Program in Internal Medicine 

ПРЕДИСЛОВИЕ РЕДАКТОРОВ 
РУССКОГО ПЕРЕВОДА 
 
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…=!3ше…,L -3…*ц,L Cече…, , C%че*. 
l/ 3"е!е…/, ч2% .2= *…,г= %*=›е2“  ,…2е!е“…%L , C%леƒ…%L 
дл  ш,!%*%г% *!3г= "!=чеL, !=K%2=ю?,. " !=ƒл,ч…/. %2!=“л . мед,ц,…“*%L C!=*2,*,.  
 
 
Ïðîôåññîð, ä. ì. í. l. j. jе"!=, 
äîöåíò, ê. ì. í. ~. b. `ле*“ее…*% 

Фармакотерапия неотложных состояний 
XII

СПИСОК СОКРАЩЕНИЙ 

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