ЭНДОГЕННЫЕ ЭТАНОЛ И АЦЕТАЛЬДЕГИД В МЕХАНИЗМАХ РЕГУЛЯЦИИ ЖИЗНЕДЕЯТЕЛЬНОСТИ ОРГАНИЗМА ДИКИХ ЖИВОТНЫХ НА СЕВЕРЕ

observation.
In control experiments (18 animals) with subcutaneous 

injections of saline and mixture of karbodiamid with BSA in alcohol 
dependent rats, significant changes of animals water and ethanol intake 
didn’t observe.

In animals administered with the conjugated A-II-BSA, unlike rats 

control group revealed increase of antibody titers to A-II, as well as 
an increase 100 and more times of A-II concentrations in the blood 
plasma. The same increase of A-II activity was also observed during the 
active immunization of intact nonlinear rats  against A-II [2, 3].

These data suggest that not only the exogenous administration of A
II, but also increase
of
the endogenous concentration of A-II in 

response to the active immunization of rats by conjugated A-II inhibits 
the ethanol intake in alcohol-dependent animals.

Reducing reception Ethanol intake reduction during increasing of the 

endogenous A-II activity was demonstrated in other experiments [4]. 
Unlike other methods of the endogenous renin-angiotensin system 
activation, immunization against A-II leads to long-term changes in 
ethanol intake, and can be considered as a potential method of 
alcoholism treatment.
Literature cited.
1.Grupp L.A., Killian M., Perlanski E., Stewart R.B. Angiotensin 

II reduces voluntary alcohol intake in the rat.
Pharmacol Biochem 

Behav., 29 № 3, 479-82 (1988).

2.Kelesheva, L.F. Angiotensins in the mechanisms of drinking, feeding 

and alcohol motivations. J. of High Nerv. Activ., № 44, 65-74 (1994).

3.Kotov A.V., Tolpygo S.M., Pevtsova E.I., Obukhova M.F. Protein
peptide complexes in the mechanisms of inborn and learned behavior 
patterns. Vestn Ross Akad Med Nauk. № 4, 36-43 (2001).

4.Maul B., Krause W., Pankow K., Becker M., Gembardt F., Alenina N., 

Walther 
T., 
Bader 
M., 
Siems 
W.E. 
Central angiotensin 

II controls alcohol consumption via its AT1 receptor. FASEB J., 19 № 
11,1474-81 (2005).

5.Tolpygo S.M. Conjugated forms of angiotensin II and beta-endorphin in 

systemic organization of goal-oriented behavior.Vestn Ross Akad Med 
Nauk. 1999;(6):52-6. Russian.

DOI:10.12737/12367

ЭНДОГЕННЫЕ ЭТАНОЛ И АЦЕТАЛЬДЕГИД В МЕХАНИЗМАХ  РЕГУЛЯЦИИ 

ЖИЗНЕДЕЯТЕЛЬНОСТИ ОРГАНИЗМА ДИКИХ ЖИВОТНЫХ НА СЕВЕРЕ

1Б.М. Кершенгольц, 1,3О.Н. Колосова, 2В.В. Шаройко

1Институт биологических проблем криолитозоны СО РАН. г. Якутск

2Санкт-Петербургский государственный университет, г. Санкт-Петербург

3Медицинский институт СВФУ им. М.К.Аммосова, г. Якутск

kerschen@mail.ru

Ключевые слова: эндогенные этанол и ацетальдегид, адаптация, 

Север, алкогольдегидрогеназа и альдегиддегидрогеназа, дикие животные.