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ВНУТРИ- И МЕЖСИСТЕМНЫЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ГОМЕОСТАЗА КАЛИЯ В ОНТОГЕНЕЗЕ

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Артикул: 623365.01.99
Айзман, Р. И. ВНУТРИ- И МЕЖСИСТЕМНЫЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ГОМЕОСТАЗА КАЛИЯ В ОНТОГЕНЕЗЕ / Р. И. Айзман. - Текст : электронный // Znanium.com. - 2017. - №1-12. - URL: https://znanium.com/catalog/product/529146 (дата обращения: 29.03.2024)
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statistically insignificant.
This parameter tended to decrease in 

passive rats (by 9.1%), but increased in active animals (by 34.4% 
compared 
to 
the 
baseline). 
Passive 
specimens 
demonstrated 
an 

insignificant decrease in TFL on day 1 after the induction of stroke 
(by 7.2% compared to the baseline). By contrast, this parameter was 
revealed to increase by 26.1% in active rats (p<0.05). No significant 
changes were found in VT of animals. On day 3 of the post-stroke 
period, all rats were characterized by the following changes in TFL 
(p<0.05
compared to the baseline): decrease by 13.6% in passive 

specimens, and increase by 35.2% in active animals. During this stage 
of observations the level of VT remained practically unchanged in 
passive rats, but slightly increased in active specimens (by 19.7%). On 
day 7 after modeling of stroke, statistically significant changes in 
TFL were observed only in active animals (45.0% increase compared to 
the baseline, p<0.05). By contrast, this parameter tended to decrease 
by 13.1% in passive rats. Variations in
VT during this period were 

similar in behaviorally passive and active specimens (increase by 11.7 
and 37.7%, respectively, compared to the baseline).

Hence, behaviorally passive and active rats with stress-induced 

hemorrhagic stroke are characterized by opposite changes only in the 
perceptual 
component 
of 
nociception. 
The 
observed 
increase 
in 

nociceptive sensitivity of passive specimens is consistent with the 
results of clinical observations, which illustrate the development of 
post-stroke pain syndrome [5]. We revealed that the perceptual 
component of nociception in behaviorally active animals is diminished 
during the post-stroke period. It is a new fact in studying the 
consequences 
of 
stress-induced 
hemorrhagic 
stroke. 
These 
data 

illustrate the specifics of changes in pain sensitivity of specimens 
with different stress resistance at various stages of the post-stroke 
period.

REFERENCES
1.
A. Yu. Abramova, S. S. Pertsov, A. Yu. Kozlov, et al., 

Byull. Eksp. Biol. Med., 155, No. 4, 404-409 (2013).

2.
N. O. Ivannikova, S. S. Pertsov, and V. V. Krylin, Byull. 

Eksp. Biol. Med., 153, No. 5, 653-658 (2012).

3.
A. Yu. Kozlov, A. Yu. Abramova, V. V. Chekhlov, et al., 

Byull. Eksp. Biol. Med., 159, No. 6, 676-680 (2015).

4.
E. V. Koplik, Vestn. Nov. Med. Tekhnol., 9, No. 1, 16-18 

(2002).

5.
R. A. Harrison and T. S. Field, Cerebrovasc Dis., 39, No. 3
4, 190-201 (2015).

DOI:10.12737/12277

ВНУТРИ- И МЕЖСИСТЕМНЫЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ГОМЕОСТАЗА 

КАЛИЯ В ОНТОГЕНЕЗЕ

Р.И.Айзман

ФГБОУ ВПО «Новосибирский государственный педагогический 

университет» (ректор – А.Д.Герасёв)

aizman.roman@yandex.ru