НОВЫЙ ПОДХОД К ПОВЫШЕНИЮ РЕЗИСТЕНТНОСТИ ОРГАНИЗМА К ВИРУСНОЙ ИНФЕКЦИИ
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НИИ ноpмальной физиологии им. П.К. Анохина
Год издания: 2015
Кол-во страниц: 4
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decrease in T4 concentration. Unlike males decrease of T4 concentration was accompanied by 14% reduction of T3 and 17% reduction of fT3 serum levels. After 10 weeks of exposure of male rats to DDT a statistically significant 12%, 13%, and 14% decrease of serum T3, fT3 and %fT3 levels compared to the control was observed, respectively. Reduction of thyroglobulin serum content by 11% as compared to the previous period and by 14% to the control group was also revealed. Quantification of serum concentration of T3 in female rats showed a 28% and 7% decrease compared to 6 weeks levels and to the control levels, respectively. fT3 concentrations also reduced by 21% and 28% compared to previous experimental and control levels. Concentration of serum thyroglobulin decreased by 8% as compared to both the control group and the 6 weeks period experimental group. The only difference in control female and male thyroid status observed was higher serum concentration of T3 and fT3 after 6 week period and T3 after 10 week period in female rats. The study revealed that prolonged exposure to low doses of DDT affected the rat thyroid status. After 6 weeks, there was a reduction in the concentration of T4 in serum rats of both sexes, but in females there was a decrease of T3 levels in systemic circulation. After 10 weeks of the experiment, the levels of T4 were upregulated in the males, while in females we found a tendency to fT4 and T4 reduction. T3 lower concentrations resulted in increase of the percentage of fT3 compared to the control rats. Thus, a long-term exposure to low doses of DDT changes the thyroid status of male and female rats and reduces the conversion of T4 to the most active form of thyroid hormone – T3, as well as decreases thyroglobulin synthesis and, consequently, the production of T4. Distinction of male and female thyroid status after exposure to low doses of DDT was faster developing decrease in the serum concentration of thyroglobulin and T4 in females. References. 1. N. V. Yaglova, V. V. Yaglov //Vestn. Ross. Akad. Med. Nauk. 2012. No 3. P56-61. 2. Vandenberg L., Colborn T., Hayes T., et al. //Endocrine Reviews. 2012. V.33. No.3. P. 378–455. 3. Hygienic Requirements to Foodstuff Safety and Nutritive Value. SanPin 2.3.2.1078-01. 2008 DOI:10.12737/12499 НОВЫЙ ПОДХОД К ПОВЫШЕНИЮ РЕЗИСТЕНТНОСТИ ОРГАНИЗМА К ВИРУСНОЙ ИНФЕКЦИИ Ямковая Т.В.* , Ямковой В.И.**, Поляков Л.М.** *ООО «Виталанг», **НИИ биохимии, Новосибирск, Россия yam_tv@mail.ru Предложен новый подход к повышению резистентности организма к вирусной инфекции, основанный на применении фракции мылкой амфифильной