СИНТЕТИЧЕСКИЙ ИНГИБИТОР ДИПЕПТИДИЛПЕПТИДАЗЫ IV МЕТИОНИЛ-2(S)-ЦИАНОПИРРОЛИДИН УВЕЛИЧИВАЕТ СТРЕСС-ИНДУЦИРОВАННУЮ АГРЕССИВНОСТЬ У КРЫС

the share of RSD is observed, in the high-frequency β2-range the values 
remain almost at the same level, as before gonadectomy. The analysis of 
the background EEG, after introduction of 17β-estradiol, showed that in 
the low-frequency ranges no changes occur. In the high-frequency ranges 
changes are minor and distinctions aren't reliable. After carrying out 
the replacement therapy (17β-estradiol+progesterone) the spectral 
analysis showed an increase in RSD in the ∆range (1-4 Hz) 
66,22±1,83. The increase in RSD in the ∆range is followed by the 

decrease in RSD in the high-frequency ranges.

The study of quantitative characteristics of SWD demonstrated that 

after gonadectomy there is a decrease in quantity and duration of SWD 
in comparison with control (from 3,75±0,44 to 2,00±0,31 and from 
9,49±1,49 sec. to 4,08±1,18 sec. (at р<0,05), respectively). After 
introduction of 17β-estradiol reliable distinctions are not revealed, 
and after an injection of 17β-estradiol with a progesterone there is a 
decrease to 1,33±0,21 and 3,2±0,85 sec. (at р<0,05), respectively. One 
of the main indicators in an assessment of epileptiformny activity on 
EEG is the peak-wave index: at deficiency of sexual hormones it 
decreased (from 1,9±0,3 to 0,82±0,23, at р<0,05), after an injection of 
17β-estradiol with a progesterone it went down to 0,64±0,17.

Thus, it has been established that fluctuation of the levels the 

ovarian steroids undoubtedly play an important role in the activity of 
brain, influencing the spectral structure of EEG and the peak-wave 
activity of its separate areas at absence-epilepsy, in particular COa. 
17β-estradiol in combination with progesterone has the desynchronizing 
impact on bioelectric activity of brain, reflecting the development of 
brake processes.

REFERENCES

1. Avyakan G. N., Oleynikova O. M., Nerobkova L.N., etc. // 

Magazine of neurology and psychiatry of S. S. Korsakov. - 2002. - N. 3. 
– P. 37-42.

2. Akhmadeev A.V., Kalimullina L.B., Minibayeva Z.R. etc. // 

Bulletin of experimental biology and medicine. – 1999. – V. 128, N. 10. 
– P. 466-470. 

3. Kabak Ya.M. Praktikum on endocrinology. – M.: Publishing house 

of MSU, 1968. – 275 pages.

4 Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 

Sydney. Academic Press – 1998.
DOI:10.12737/12485

СИНТЕТИЧЕСКИЙ ИНГИБИТОР ДИПЕПТИДИЛПЕПТИДАЗЫ IV МЕТИОНИЛ-2(S)
ЦИАНОПИРРОЛИДИН УВЕЛИЧИВАЕТ СТРЕСС-ИНДУЦИРОВАННУЮ 

АГРЕССИВНОСТЬ У КРЫС

Н.Н.Хлебникова, Н.А.Крупина

Лаборатория общей патологии нервной системы (зав. – член-корр. РАН 

В.К.Решетняк) ФГБНУ «Научно-исследовательский институт общей патологии 

и патофизиологии», Москва

nanikh@yandex.ru – Н.Н. Хлебникова