Влияние селективной блокады A2A/D-адренорецепторов на сердечно-сосудистую систему растущих крыс

The reduced tissue oxygen uptake demands of an organism 

results in a reduction of erythropoiesis and erythrocyte production up 
to 
level 
of 
necessary 
oxygen 
tissue 
supply. 
For 
example, 

posttransfusional polycythaemia in rat leads to a well known in 
experimental hematology reduction in renal erythropoietin production 
and erythropoiesis reduction that was provoked by reduced oxygen uptake 
tissue demands. We estimated typical adaptive changes in EI cell 
components, resulted in erythropoiesis reduction. Their further 
investigations 
with 
EI 
culture 
technique 
on 
posttransfused 

polycythaemic 
rat 
model 
revealed: 
1. 
sensitivity 
reduction 
to 

additional erythropoietin in culture by bone marrow macrophages, that 
prevents new EI formation; 2. lack of EI erythroid cells ability to 
respond by mitotic activity rise to erythropoietin added to culture; 3. 
EI macrophages to reduce endogenous erythropoietin production, at the 
same time markedly increase expression, synthesis and secretion of 
erythropoiesis inhibiting cytokines –
TNF-alpha, IL-6; 4. lymphoid 

cells contact inhibition with 1 class and reconstruction  class EI; 5. 
EI macrophages reduce an erythropoietic activity microenvironment in EI 
by decreasing both synthesis and secretion of glucose-amino-glycan 
fractures total amount [2]. 

References.
1.
Zakharov 
Yu.M. 
Regulation 
of 
erythropoiesis 
in 

erythroblastic islands of bone marrow. Russian J.of Physiology. 97(9): 
980-994, 2011; 

2.
Zakharov Yu.M., Melnikov I.Yu., Shevyakov S.A., Tishevskaya 

N.V. Mechanisms of erythropoiesis suppression in posttransfused 
polycythaemia. Bulletin of Ural Med. Acad. Sci. 3(49): 100-103. 2014; 

3.
Zakharov Yu.M., Rassokhin A.G. Erythroblastic island. M., 

Meditsina: 2002. 280p. 

4.
Zakharov Yu.M., Feklicheva I.V. Influence of erythropoietin 

and T-lymphocytes on erythropoiesis in culture of erythroblastic 
islands of bone marrow in polycythaemic rat. Bulletin of Ural Med. 
Acad. Sci. 1: 81-84. 2009.

5.
Bessis M. Reinterpretation des frottis sanguins. Masson. 

Paris. 107.

DOI:10.12737/12265

ВЛИЯНИЕ СЕЛЕКТИВНОЙ БЛОКАДЫ Α2A/D-АДРЕНОРЕЦЕПТОРОВ НА 

СЕРДЕЧНО-СОСУДИСТУЮ СИСТЕМУ РАСТУЩИХ КРЫС

Т.Л. Зефиров1, Л.И. Хисамиева1, Н.И. Зиятдинова1, Л.И. Фасхутдинов1, А.Л. 

Зефиров2

1Кафедра анатомии, физиологии и охраны здоровья человека (зав. каф. 
докт. мед. наук, проф. Т.Л.Зефиров) Казанского (Приволжского) 

федерального университета; 2Кафедра нормальной физиологии (зав. каф. –

чл.-корр. РАН, проф. А.Л. Зефиров) Казанского государственного 

медицинского университета

zefirovtl@mail.ru