МЕХАНИЗМЫ РЕГЕНЕРАЦИИ ГЕМОПОЭЗА ПРИ МИЕЛОИНГИБИРУЮЩИХ ВОЗДЕЙСТВИЯХ

specific formalism for the links between different functional systems. 
It also does not explain the origin of traditional psychological 
phenomena and functions from the activity of functional systems. 
Finally, it does not address the issue of development and dynamics of 
distributed neuronal systems that do not contribute to adaptive results 
of the organisms. 

All these questions are the subject of the extended functional 

systems theory (EFST). It introduces the concept of cognitive 
hypernetwork of the brain (cognitome).The vertices of this hypernetwork 
are neuronal cognitive groups (COGs) subsets of vertices from the 

underlying neural network (connectome) associated by a common cognitive 
experience. Edges between vertices in the cognitive network are formed 
by the combination of edges between of corresponding vertices in the 
neural network. They possess emergent cognitive properties not reduced 
to underlying neural connections. Thus, cogs represent nodes in the 
cognitome and edges are links between them.

Building on the concept of cogs and their links, we can represent 

cognitome as a network. This allows introducing mathematical formalism 
into description of cognitive experience. In terms of algebraic 
topology, COG is a relational simplex or hypersimplex, It's base is the 
simplex from vertices of the underlying N-network and its apex is the 
vertex possessing a new quality at the higher-level K-network. 
Hypernetworks generalize networks and hypergraphs, provide formalism 
for description of emergent phenomena in the multi-level systems, and 
allow modeling much more complex structures than networks and 
hypergraphs. According to the EFST, these hyperstructures compose a 
unified system of individual experience of the organism its 

cognitome.

LITERATURE
1. P.K. Anokhin. Essay on Physiology of Functional Systems. 1975, 

Medicine, Moscow.
DOI:10.12737/12261

МЕХАНИЗМЫ РЕГЕНЕРАЦИИ ГЕМОПОЭЗА ПРИ МИЕЛОИНГИБИРУЮЩИХ 

ВОЗДЕЙСТВИЯХ

Дыгай А.М., Жданов В.В.

Федеральное государственное бюджетное научное учреждение «Научно
исследовательский институт фармакологии и регенеративной медицины имени 

Е.Д. Гольдберга», Томск, Россия

Важное значение в восстановлении гемопоэза при миелоингибирующих 

воздействиях 
принадлежит 
цитокинам, 
продуцируемым 
элементами 

кроветворного микроокружения. В выработке данных веществ принимает 
участие 
целый 
ряд 
сигнальных 
каскадов, 
знание 
роли 
отдельных 

компонентов которых необходимо для разработки новых способов и средств 
для коррекции гипопластических состояний. Цель исследования. Определить 
общие закономерности и особенности сигнальной трансдукции в регуляции 
кроветворения в норме и при действии различных цитостатических